S.E.M.I.: Side Effects May Include...
S.E.M.I. is a cooperative online game about escaping from a special clinic. Here you and up to 3 of your feeble-minded loyal friends in the role of patients fight with the staff and other patients and find…
S.E.M.I.: Side Effects May Include... is an arcade developed by Two Horn Unicorn, released 23 January 2026 on PC (Microsoft Windows).
What S.E.M.I.: Side Effects May Include... is
S.E.M.I.: Side Effects May Include... is an arcade game developed by Two Horn Unicorn and released in 2026. It is available on PC (Microsoft Windows) only. It runs on Unreal Engine 5.
The premise, in the publisher's words
S.E.M.I. is a cooperative online game about escaping from a special clinic. Here you and up to 3 of your feeble-minded loyal friends in the role of patients fight with the staff and other patients and find yourself in unexpected situations. Teamwork is essential, as randomized events and experimental drugs will lead your party into unpredictable mayhem. Pop pills with your friends as you cooperate to gain your freedom.
How it plays
It is played from a third person perspective. Its themes are action, comedy and party. It is a single-player game with no multiplayer component. Available modes: Co-operative, Multiplayer and Single player.
What it launched against
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